ROLES OF PROLACTIN AND GONADOTROPIN-RELEASING HORMONE IN RHEUMATIC DISEASES

      Prolactin (PRL), a peptide hormone, is produced by lactotrophs in the anterior pituitary gland and stimulates mammary growth and differentiation. Pituitary secretion of PRL is stimulated by suckling and stress and is restricted by hypothalamic dopamine.
      • Neill J.D.
      • Nagy G.M.
      Prolactin secretion and its control.
      It is now recognized that PRL is produced in a number of sites outside the pituitary, including the brain and lymphocytes.
      • Ben-Jonathan N.
      • Mershon J.L.
      • Allen D.L.
      • et al.
      Extra pituitary prolactin: Distribution, regulation, functions, and clinical aspects.
      PRL is important in maintaining immune competence
      • Walker S.E.
      • McMurray R.W.
      • Houri J.M.
      • et al.
      Effects of prolactin in stimulating disease activity in systemic lupus erythematosus.
      • Walker S.E.
      • Allen S.H.
      • Hoffman R.W.
      • et al.
      Prolactin: A stimulator of disease activity in systemic lupus erythematosus [review].
      • Weigent D.A.
      Immunoregulatory properties of growth hormone and prolactin.
      • Yu-Lee L.-Y.
      Molecular actions of prolactin in the immune system.
      and has the potential to play a role in the pathogenesis of autoimmune illnesses.
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